Progesterone reduces depressive behavior of young ovariectomized, aged progestin receptor knockout, and aged wild type mice in the tail suspension test
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چکیده
منابع مشابه
Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice.
Progesterone can enhance cognitive performance among young and aged mice; however, the mechanisms underlying these effects of progesterone are not well-understood. Aged, mice which lack functional progestin receptors (PRKO), or wildtype mice were administered progesterone (10mg/kg, SC), or vehicle, and learning/memory was evaluated. Progesterone, compared to vehicle, produced a conditioned plac...
متن کاملGenotype differences in behavior and tyrosine hydroxylase expression between wild-type and progesterone receptor knockout mice.
Progesterone receptor (PR) activation can modulate the expression of male sexual behavior, both acutely in adulthood as well as during development, through long lasting effects on neural differentiation. One mechanism by which PR activation may affect behavior, during either epoch of life, is through alterations of the dopaminergic system. We investigated the effects of PR deletion on the sensi...
متن کاملProximal gut mucosal epithelial homeostasis in aged IL-1 type I receptor knockout mice after starvation.
BACKGROUND Previous studies have shown that starvation induces small bowel atrophy, and that atrophy diminishes with aging. In this experiment, we assessed whether starvation-induced atrophy of proximal gut mucosa is associated with the Interleukin-1 receptor (IL-1R) signaling pathway in aged mice. MATERIALS AND METHODS Thirty 26-month-old IL-1R knockout mice and age-matched wild-type C57BL/6...
متن کاملAnxiolytic activity of progesterone in progesterone receptor knockout mice.
Progesterone is an anxiolytic steroid that could play a role in the regulation of anxiety in women. However, the mechanism by which progesterone decreases anxiety is incompletely understood. Progesterone affects the function of the brain by two distinct mechanisms. Progesterone regulates reproductive behavior by activating intracellular progesterone receptors (PRs). In addition, progesterone is...
متن کاملThe tail suspension test.
The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that are expected to affect depression related behaviors. Mice are suspended by their tails with tape, in such a position that it cannot escape or hold on to nearby surfaces. During this test, typically six minutes in duration, the resulting escape ...
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ژورنال
عنوان ژورنال: Journal of Psychopharmacology
سال: 2009
ISSN: 0269-8811,1461-7285
DOI: 10.1177/0269881109349836